(111)Indium-transferrin for localization and quantification of gastrointestinal protein loss.
Identifieur interne : 002063 ( Main/Exploration ); précédent : 002062; suivant : 002064(111)Indium-transferrin for localization and quantification of gastrointestinal protein loss.
Auteurs : RBID : pubmed:19662583English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Proteins.
- chemical , diagnostic use : Indium, Indium Radioisotopes, Transferrin.
- radionuclide imaging : Protein-Losing Enteropathies.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Male, Middle Aged.
Abstract
To evaluate the indium-111 ((111)In)-transferrin method as a means of localization and quantification of gastrointestinal protein loss.
DOI: 10.1080/00365520903144406
PubMed: 19662583
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">(111)Indium-transferrin for localization and quantification of gastrointestinal protein loss.</title><author><name sortKey="Simonsen, Jane Angel" uniqKey="Simonsen J">Jane Angel Simonsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Odense University Hospital, Odense C, Denmark. Jane.Simonsen@ouh.regionsyddanmark.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Nuclear Medicine, Odense University Hospital, Odense C</wicri:regionArea></affiliation></author><author><name sortKey="Braad, Poul Erik" uniqKey="Braad P">Poul-Erik Braad</name></author><author><name sortKey="Veje, Annegrete" uniqKey="Veje A">Annegrete Veje</name></author><author><name sortKey="Gerke, Oke" uniqKey="Gerke O">Oke Gerke</name></author><author><name sortKey="Schaffalitzky De Muckadell, Ove B" uniqKey="Schaffalitzky De Muckadell O">Ove B Schaffalitzky De Muckadell</name></author><author><name sortKey="H Ilund Carlsen, Poul Flemming" uniqKey="H Ilund Carlsen P">Poul Flemming Høilund-Carlsen</name></author></titleStmt><publicationStmt><date when="2009">2009</date><idno type="doi">10.1080/00365520903144406</idno><idno type="RBID">pubmed:19662583</idno><idno type="pmid">19662583</idno><idno type="wicri:Area/Main/Corpus">001D47</idno><idno type="wicri:Area/Main/Curation">001D47</idno><idno type="wicri:Area/Main/Exploration">002063</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Indium (diagnostic use)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Male</term><term>Middle Aged</term><term>Protein-Losing Enteropathies (radionuclide imaging)</term><term>Proteins (analysis)</term><term>Transferrin (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium</term><term>Indium Radioisotopes</term><term>Transferrin</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Protein-Losing Enteropathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the indium-111 ((111)In)-transferrin method as a means of localization and quantification of gastrointestinal protein loss.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19662583</PMID><DateCreated><Year>2009</Year><Month>11</Month><Day>20</Day></DateCreated><DateCompleted><Year>2010</Year><Month>03</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1502-7708</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>10</Issue><PubDate><Year>2009</Year></PubDate></JournalIssue><Title>Scandinavian journal of gastroenterology</Title><ISOAbbreviation>Scand. J. Gastroenterol.</ISOAbbreviation></Journal><ArticleTitle>(111)Indium-transferrin for localization and quantification of gastrointestinal protein loss.</ArticleTitle><Pagination><MedlinePgn>1191-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00365520903144406</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the indium-111 ((111)In)-transferrin method as a means of localization and quantification of gastrointestinal protein loss.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fourteen patients and 15 healthy subjects underwent an (111)In-transferrin study consisting of abdominal scintigraphy, whole-body counting measurement and determination of plasma activity of (111)In during the course of 5 days. Two of the patients went through a subsequent chromium-51-trichloride test with analysis of radioactivity in faeces in order to compare the results of the two methods.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The patients had a mean +/-SEM whole-body loss of (111)In of 10.9+/-2.9% for 96 h, while the healthy controls lost 1.8+/-1.3% (p=0.0045). The decay in plasma activity followed biexponential kinetics. The characteristic plasma transit time was 5.0+/-1.0 h in patients and 12.1+/-1.5 h in controls (p=0.0007). Scintigraphically, patients had obvious abdominal foci of activity, while the control subjects showed diffuse activity. Anatomic localization of the leaking spot seemed more uncertain. By comparison with the (51)CrCl(3) test, the loss of radio-labelled protein appeared to be in the same order of magnitude.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Quantification of gastrointestinal protein loss can be done without collecting faeces. Normal subjects have a loss of a few per cent, making the (111)In-transferrin method comparable with the former standard using (51)CrCl(3). Plasma measurements of (111)In are not predictive of the magnitude of the loss. Scintigraphic localization of the site of the loss needs to be optimized, for instance by serial imaging or image fusion with an anatomical modality.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simonsen</LastName><ForeName>Jane Angel</ForeName><Initials>JA</Initials><Affiliation>Department of Nuclear Medicine, Odense University Hospital, Odense C, Denmark. Jane.Simonsen@ouh.regionsyddanmark.dk</Affiliation></Author><Author ValidYN="Y"><LastName>Braad</LastName><ForeName>Poul-Erik</ForeName><Initials>PE</Initials></Author><Author ValidYN="Y"><LastName>Veje</LastName><ForeName>Annegrete</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gerke</LastName><ForeName>Oke</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Schaffalitzky De Muckadell</LastName><ForeName>Ove B</ForeName><Initials>OB</Initials></Author><Author ValidYN="Y"><LastName>Høilund-Carlsen</LastName><ForeName>Poul Flemming</ForeName><Initials>PF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Gastroenterol</MedlineTA><NlmUniqueID>0060105</NlmUniqueID><ISSNLinking>0036-5521</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Transferrin</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Protein-Losing Enteropathies</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Proteins</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Transferrin</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>8</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>8</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">913697358</ArticleId><ArticleId IdType="doi">10.1080/00365520903144406</ArticleId><ArticleId IdType="pubmed">19662583</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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